基因+病毒=疾病(雙語有聲)
作者：ember
來源：滬江論壇
2010-07-02 10:24
詼諧的語言，生動的內(nèi)容一分鐘快速掌握科技最新動態(tài)
Mouse Disease Needs Gene plus Viral Infection
小鼠患病需要基因與病毒感染雙重作用
Crohn's disease is a real pain in the gut. This inflammatory disorder can lead to some serious intestinal difficulties. And heredity is partly to blame: some 30 different genes enhance susceptibility. But not everyone who has the genes gets Crohn's.
克羅恩病（結腸克隆氏病、節(jié)段性回腸炎）對腸胃來說可真是一種折磨！這種炎癥性疾病可導致某些嚴重的腸道癥狀。而部分原因要歸結為——遺傳：有30種不同的基因可增高克羅恩病的易感性，但也并非每一個擁有這種基因的人就會得克羅恩病。
Now scientists find that those with one type of risky gene may also need to catch a virus to trigger the disease. The results appear in the journal Cell.
如今，科學家們發(fā)現(xiàn)擁有某一類型這種基因的人或許感染上一種病毒后才會引發(fā)克羅恩病。這一研究結果發(fā)表在《細胞》雜志上。
Doctors have long suspected that some sort of virus might precipitate autoimmune disorders, like lupus or multiple sclerosis. But in the case of Crohn's, researchers stumbled across the connection by accident.
一直以來，醫(yī)生們就懷疑某些類型的病毒有可能促使自身免疫功能紊亂，如紅斑狼瘡、多發(fā)性硬化癥等。但就克羅恩病而言，研究人員是在偶然中才發(fā)現(xiàn)這其中的聯(lián)系。
They were studying mice that carry a version of a gene associated with Crohn's. These animals develop gut problems similar to those seen in humans. Then the researchers started keeping the animals in clean cages. Really clean cages, in which the bedding, food, and water are sterilized. And the squeaky clean mice, even with the risky gene, stayed healthy. But when the scientists exposed the animals to a common virus, they came down with mouse Crohn's.
當時，研究人員在對攜有與克羅恩病相關基因的實驗鼠進行研究，這些實驗鼠患有與人類極為相似的腸道問題。研究人員將它們放入潔凈的籠中，這可是真正的一塵不染——它們的寢具、食物、飲水全都是經(jīng)過消毒無菌的。而這些異常潔凈的小實驗鼠即使攜帶了高?；颍惨廊唤】底聣?。但是，一旦將它們暴露在有普通病毒的環(huán)境中，這些實驗鼠就會患上鼠類的克羅恩病。
The research shows that some illnesses may require a combination of genetic predisposition and infection. Info which could lead to new treatment strategies.
這項研究表明，有些疾病是遺傳基因易感性和病毒感染的共同作用引發(fā)的。而這一信息也指出了一種新的治療策略。
-Karen Hopkin
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